Aqemia is a next-generation pharmaceutical company generating one of the fastest drug discovery pipelines in the world. Our mission is to develop groundbreaking, fast-acting drug candidates for scores of severe diseases. What sets us apart is our proprietary quantum mechanical and statistical algorithms that power generative artificial intelligence to design new drug candidates.
The velocity and precision of our technology platform allows us to scale drug discovery projects as technology projects.
We’ve grown to a team of over 45 highly motivated and spirited individuals standing at the intersection of Chemistry, Machine Learning, Physics, and Software Engineering.
We are proud to announce that we've raised $12 million from leading VCs.
If this sounds exciting to you, come and join us!
The difference you’ll make
We are seeking a talented and experienced Computational Chemist, aka Drug Hunter, to work alongside our core team and make an impact on a critical challenge: identifying drug candidates to cure major diseases.
This role calls for a strong sense of ownership and a drive to improve the already existing technology while maintaining its stability and robustness. The selected candidate will have keen interest in interdisciplinarity and will be quick on the uptake when faced with new concepts/frameworks.
What you'll do:
As a Senior Drug Hunter you will...
- Be a key member of an interdisciplinary team made up of medicinal chemists, computational chemists and theoretical physicists
- You will improve our drug discovery pipeline and work with the team to come up with tailored approaches for each project to produce new drug candidates.
- Drive tech projects aiming at making our technology faster, more precise, more scalable and more robust
- Help define new deliverables and roadmap for the Drug Hunter technology and help deliver them
- Improve Aqemia binding affinity computation pipeline through development of specific modules
- Leverage your expertise in computational chemistry, software development and drug discovery projects to expand the spectrum of protein targets that can be addressed by our technology
- Leverage feedback from experiments to identify, develop and implement improvements in our computational pipeline
- Work hand-in-hand with the ML and Data teams to leverage groundbreaking, disruptive algorithms in your drug discovery projects, and offer your drug hunter perspective and ideas as input to the development of tools
- Have an acute sensitivity to code quality, robustness and reproducibility
Who you are:
You feel pride in every step forward, however big, or small; to you, each challenge represents a well-executed venture to support Aqemia Drug Discovery projects. We look for people who take responsibility, set their standards high and see every failure as an opportunity to learn. You’re looking for an environment where you can thrive. With opportunities to challenge yourself and a talented team by your side, you’ll find what you’re looking for at Aqemia.
More specifically, you
- Are a Computational Chemist, Drug Designer, a Cheminformatician, a Structural Bioinformatician, or a Computational Biologist
- Are an object-oriented programmer coder who’s comfortable with object-oriented programming in Linux/UNIX environments.
- Are a team player with strong project leadership skills and a demonstrated ability to deliver results.
- Have an inquiring mind, you are proactive and eager to learn
- Have a desire to grow, both professionally and personally, and you want to help others grow with you
- Have the ability to thrive in a fast-paced environment
- Feel strongly that in silico/AI can have major impact when it comes to identifying new drugs
- 4+ years of pharma/biotech experience with a focus on computational chemistry
- Hands-on experience in computational chemistry applied to drug discovery using state-of-the-art structure-based or ligand-based methods, including virtual screening, molecular docking, structure-activity relationship analysis, multi-property optimization-based compound design
- Extensive knowledge of protein structures, functions and protein-ligand interactions
- Intermediate to advanced python programming
- Knowledge of computational chemistry packages: RDKIT, OpenMM, parmed, GROMACS, Ambertools, MDAnalysis, …
- Ph.D. and post-doctoral experience as well as a track record of technical excellence as shown by peer reviewed publications and inventorship status on patents.
- Proficiency in small molecule ligand discovery (esp. SBDD) and cheminformatics techniques including protein homology modeling, small molecule docking and pharmacophore hypothesis, in silico virtual screening, QSAR and ADMET properties modeling, database searches, combinatorial library design, FEP based affinity predictions, molecular dynamics simulations, etc.
Our Workplace Environment:
- Fast-paced, intellectually and scientifically demanding, results-driven.
- Rapidly growing team of +45 people from world-class institutions (AstraZeneca, GSK, Sanofi, Harvard, Ecole Normale Supérieure, Ecole Polytechnique, BCG).
- Flexible work setup with up to 2 days of remote work per week at your convenience.
- Great bright premises conveniently located in center of Paris (1 Bd Pasteur).
- Pleasant and stimulating work environment: Regular drinks with colleagues, weekly knowledge sharing presentations, weekly food delivery, welcoming breakfast for new arrivals, participation to public and bike transportation costs.
- Working language: Mix of English and French.
Should you wish to apply for this position please send us your resume at firstname.lastname@example.org
We are growing fast, if you feel that you don't fit this job description but you’re still excited to join, then please get in touch!
Aqemia is an Equal Employment Opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender perception or identity, national origin, age, marital status, disability status or any other basis under applicable law.